ackground : In diabetic mellitus, many patients complain seveal symptoms cause by diabetic neuropathy. Those symptoms are including nausea, vomiting and abdominal discomfort. Erythromycin, a macrolide antibiotic, has recently been motilin like
effect on
gastointestinal muscles, which induces phase 3 activity that start in the stomach. Radioactive
isotope is now best method for measuring gastric emptying time.
Methods : First study is measuring of tincolloid labeling efficiency in gastric juice. Second
study, we are evaluated the effect of erythromycin on patients with delayed gastric emptying
and healthy subjects using the radionuclide technique. Twelve patients with diabetic
gastoparesis and ten control subjects join in our study. Gastric emptying of solid food was
determined using 99mTc tincolled egg. After 3 day, each patients was performed with same
method after injection of intravenous erythromycin 200 mg.
Results : Labelling efficiency of 99mTc tincolloid is very satisfaction (mean±SD=87.2±
4.3%). Gastric emptying time is delayed in diabetic gastroparesis patients domparison with
control subjects. After erythromycin injection, gastric emptying time is shortened. The time is
about 1/3 than pre-eythromycin injection in patients.sixty minutes after ate meals, mean
ejection fraction was 19.3% (pre-EM inject), 64.4% (post EM inject), 51.9% (control group).
Conclusion : Erythromycin, mimic effect of the motilin, appears to be a very powerful
gastrokinetic drug. So that erythromycin may have therapeutic effect in patient with severe
diabetic gastroparesis.
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